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產(chǎn)品規(guī)格
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BN41548R-50ul
50ul
￥1486.00
交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA
BN41548R-100ul
100ul
￥2360.00
交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA
BN41548R-200ul
200ul
￥3490.00
交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA
產(chǎn)品描述
| 英文名稱 | Chromogranin A |
| 中文名稱 | 嗜鉻粒素A抗體 |
| 別 名 | beta Granin; CGA; CHG A; CHGA; Chromogranin A parathyroid secretory protein 1; Chromogranin A precursor; ChromograninA; Pancreastatin; Parastatin; Parathyroid secretory protein 1; Pituitary secretory protein I; SP I; SP1; SPI; Vasostatin; ER-37; CMGA_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 細胞定位 | 細胞漿 細胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CGA:421-470/457 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008]. Function: Pancreastatin strongly inhibits glucose induced insulin release from the pancreas. Subunit: Interacts with SCG3. Subcellular Location: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. Post-translational modifications: Sulfated on tyrosine residues and/or contains sulfated glycans. O-glycosylated with core 1 or possibly core 8 glycans. Similarity: Belongs to the chromogranin/secretogranin proteinfamily. SWISS: P10645 Gene ID: 1113 Database links: Entrez Gene: 1113 Human Entrez Gene: 12652 Mouse Omim: 118910 Human SwissProt: P10645 Human SwissProt: P26339 Mouse Unigene: 150793 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 嗜鉻粒素A蛋白存在與很多組織中：胃腸道內(nèi)分泌細胞和類癌、甲狀旁腺、垂體前葉、腎上腺髓質(zhì)、神經(jīng)節(jié)、副神經(jīng)節(jié)、胰島、甲狀腺C細胞等組織和其來源的腫瘤都表達該成分.嗜鉻素A（CgA）屬于可溶性的酸性蛋白，主要存在于神經(jīng)內(nèi)分泌細胞的分泌顆粒中，也存在于含有分泌顆粒的內(nèi)分泌細胞和神經(jīng)內(nèi)分泌細胞來源的腫瘤細胞中。檢測循環(huán)中的免疫反應(yīng)CgA對神經(jīng)內(nèi)分泌瘤具有診斷意義。另外，CgA的免疫組織化學(xué)檢測對鑒定來源于神經(jīng)內(nèi)分泌的腫瘤起到輔助作用。 |
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