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產(chǎn)品規(guī)格
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BN40422R-100ul
100ul
￥2360.00
交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Monkey) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40422R-200ul
200ul
￥3490.00
交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Monkey) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
產(chǎn)品描述
| 英文名稱 | GLYR1 |
| 中文名稱 | 氧化還原酶GlyR1/核蛋白60抗體 |
| 別 名 | 3 hydroxyisobutyrate dehydrogenase like protein; 3-hydroxyisobutyrate dehydrogenase-like protein; BM045; Cytokine like nuclear factor n pac; Cytokine-like nuclear factor N-PAC; Glyoxylate reductase 1 homolog; GLYR1; GLYR1_HUMAN; HIBDL; N-PAC; NP60; Nuclear protein 60 kDa; Nuclear protein NP60; Nuclear protein of 60 kDa; Putative oxidoreductase GLYR1. |
| 研究領(lǐng)域 | 細胞生物 信號轉(zhuǎn)導 激酶和磷酸酶 表觀遺傳學 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Monkey, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 61kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GLYR1/NP60:21-120/553 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | NP60 is a 553 amino acid nuclear protein that regulates the phosphorylation and activation of p38 alpha in response to stress. There are five isoforms of NP60 that are produced as a result of alternative splicing events. Function: May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Subunit: Interacts with MAPK14. Subcellular Location: Nucleus. Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily. Contains 1 A.T hook DNA-binding domain. Contains 1 PWWP domain. SWISS: Q49A26 Gene ID: 84656 Database links: Entrez Gene: 84656 Human Entrez Gene: 74022 Mouse Omim: 610660 Human SwissProt: Q49A26 Human SwissProt: Q922P9 Mouse Unigene: 387255 Human Unigene: 21652 Mouse Unigene: 2639 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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