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產(chǎn)品規(guī)格
售價
備注
BN41321R-100ul
100ul
￥2360.00
交叉反應：Human(predicted:Mouse,Rat) 推薦應用：WB,ELISA
BN41321R-200ul
200ul
￥3490.00
交叉反應：Human(predicted:Mouse,Rat) 推薦應用：WB,ELISA
產(chǎn)品描述
| 英文名稱 | NFX1 |
| 中文名稱 | 核轉(zhuǎn)錄因子X盒結(jié)合蛋白1抗體 |
| 別 名 | NFX2; MGC20369; NFX 1; NFX1; Nuclear transcription factor X box binding 1; Nuclear transcription factor X box binding protein 1; Transcriptional repressor NF X1; NFX1_HUMAN. |
| 研究領(lǐng)域 | 細胞生物 免疫學 信號轉(zhuǎn)導 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, (predicted: Mouse, Rat, ) |
| 產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 124kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NFX1:881-980/1120 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | NFX1 is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. It may play a role in the inflammatory response, regulating its duration by limiting the period in which class II MHC molecules are induced by IFN gamma. The RING type zinc finger domain interacts with an ubiquitin conjugating enzyme (E2) and facilitates ubiquitination. Function: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. Subunit: Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein. Isoform 1 interacts with PABPC1 and PABPC4. Subcellular Location: Nucleus. Post-translational modifications: Isoform 3 is polyubiquitinated in the presence of HPV16 E6 protein; which leads to proteasomal degradation. Isoform 1 is not polyubiquitinated. Similarity: Belongs to the NFX1 family. Contains 8 NF-X1-type zinc fingers. Contains 1 R3H domain. Contains 1 RING-type zinc finger. SWISS: Q12986 Gene ID: 4799 Database links: Entrez Gene: 4799 Human Entrez Gene: 74164 Mouse Omim: 603255 Human SwissProt: Q12986 Human SwissProt: B1AY10 Mouse Unigene: 413074 Human Unigene: 247456 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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