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BN40686R-100ul
100ul
￥2360.00
交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：WB
BN40686R-200ul
200ul
￥3490.00
交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：WB
產(chǎn)品描述
| 英文名稱(chēng) | GDNFRA |
| 中文名稱(chēng) | GDNF家族受體α-1抗體 |
| 別 名 | GDNF Receptor alpha 1; GFRa-1; GFR alpha; GDNFR alpha; TmR1; GFR alpha-1; RETL1; RET ligand 1; TGF-beta related neurotrophic factor receptor-1; AU042498; DKFZp313E1012; DKFZp686J0156; FLJ10561; FLJ31546; GDNFR; Gdnfr alpha; GFR-ALPHA-1; GFRA1; GRFA1; LOC143381; MGC23045; Ret; RET1L; RETL1; TRNR1; GFRA1_HUMAN; GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; TGF-beta-related neurotrophic factor receptor 1. |
| 研究領(lǐng)域 | 免疫學(xué) 神經(jīng)生物學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GDNFRA:81-180/465 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq] Function: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Subunit: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Similarity: Belongs to the GDNFR family. SWISS: P56159 Gene ID: 2674 Database links: Entrez Gene: 2674 Human Entrez Gene: 14585 Mouse Omim: 601496 Human SwissProt: P56159 Human SwissProt: P97785 Mouse Unigene: 591913 Human Unigene: 88489 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GFRα-1是由68個(gè)氨基酸組成的蛋白，廣泛表達(dá)于中樞神經(jīng)系統(tǒng)和外周器官。活性亞單位由兩個(gè)GFRα-1分子中間由二硫鍵連接而成的復(fù)合物。屬于GDNFR 家族成員。 |
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